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Current Projects

Cobalt and Chromium Levels in Patients with Megaprosthetics.

PI: Nicholas Tedesco


Cell: 330-280-4155

Greetings MORI members and other interested orthopedic oncologists! I hope your holiday season is going fantastically! We presented our research ideas for looking at random serum cobalt and chromium levels in our tumor patients with megaendoprosthetics at the MSTS meeting. It is grant funded to pay for the testing in full and possibly for research department help depending on the amount requested. Accrual has been very easy and it’s only a single level obtained on these patients with nothing more asked. However, we desperately need more numbers and more institutions on board. We can furnish all the documents you need for IRB approval quickly and can even establish a contract for our IRB to oversee your part in the study if your IRB will allow the bypass that can help things move more quickly. If you are interested in helping out or have additional questions before deciding to participate, please reach out at any of my contact info below at any time. Thank you and I look forward to working with you!

Caring for the Orthopaedic Oncologic Polytrauma Patient.

PI: Lisa Ercolano

A comparison of patients who have undergone operative fixation for multiple simultaneous impending or completed long bone pathologic fractures compared to those with solitary involvement. A multi-institutional retrospective review.

Transcutaneous Oxygen as a Predictor of Wound Healing Complications in Preoperatively Radiated Soft Tissue Sarcoma.

PI: Lukas Nystrom

Orthopaedic Research and Education Foundation, OREF/MSTS Clinical Research Grant in Orthopaedic Oncology


This project is a prospective, multi-institutional effort evaluating the potential of non-invasive transcutaneous oximetry to identify patients at risk of developing wound complications following surgery for preoperatively radiated soft tissue sarcoma. 

Project completed enrollment 9/30/2020, now in data analysis phase

Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: A Prospective Randomized Controlled Tria

PI: David Greenberg


This study is a prospective, randomized, controlled multicenter trial to investigate whether the local delivery of BP as a surgical adjuvant can decrease the local recurrence rate of GCT of bone. The specific aims are to determine if BP-loaded bone cement decreases LR and provides superior results in secondary outcomes in comparison to conventional methods.

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