Tranexamic Acid in Musculoskeletal Oncology: A Randomized Control Study
PI: Kyle Sweeney
This study is a prospective, randomized, controlled multicenter trial to investigate the safety and efficacy of tranexamic acid (TXA) use in orthopaedic oncology. The study consists of two arms. The first includes patients undergoing wide resection and endoprosthetic reconstruction for malgnant bone tumors (inclusive of metastatic disease). The second arm includes patients undergoing wide resection for soft tissue sarcomas of the pelvis and lower extremity measuring >5cm. The specific aims are to determine if TXA decreases perioperative blood loss and transfusion requirements.
Caring for the Orthopaedic Oncologic Polytrauma Patient.
PI: Lisa Ercolano
A comparison of patients who have undergone operative fixation for multiple simultaneous impending or completed long bone pathologic fractures compared to those with solitary involvement. A multi-institutional retrospective review.
Transcutaneous Oxygen as a Predictor of Wound Healing Complications in Preoperatively Radiated Soft Tissue Sarcoma.
PI: Lukas Nystrom
Orthopaedic Research and Education Foundation, OREF/MSTS Clinical Research Grant in Orthopaedic Oncology
This project is a 2 year prospective, multi-institutional effort evaluating the potential of non-invasive transcutaneous oximetry to identify patients at risk of developing wound complications following surgery for preoperatively radiated soft tissue sarcoma.
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: A Prospective Randomized Controlled Tria
PI: David Greenberg
This study is a prospective, randomized, controlled multicenter trial to investigate whether the local delivery of BP as a surgical adjuvant can decrease the local recurrence rate of GCT of bone. The specific aims are to determine if BP-loaded bone cement decreases LR and provides superior results in secondary outcomes in comparison to conventional methods.